Biocatalysis
Dowpharma Scientific Publications
Please find detailed a synopsis of the papers and publications on Biocatalysis that scientists from DowpharmaSM have published and contributed to since 1998. Due to copyright law we are unable to reproduce the papers online. As such we have quoted the publication reference.
Immobilization of Cholesterol Esterase for Use in Multiple Batch Biotransformations to Prepare (-)- FTC (Emtricitabine).
Osborne, A. P.; Brick, D.; Ruecroft, G.; Taylor, I. N. Org. Process Res. & Dev. 2006, 10, 670-672.
Nitrilase-Catalysed Desymmetrisation of 3-Hydroxyglutaronitrile: Preparation of a Statin Side-Chain Intermediate.
Bergeron, S.; Chaplin, D. A.; Edwards, J. H.; Ellis, B. S. W.; Hill, C. L.; Holt-Tiffin, K.; Knight, J. R.; Mahoney, T.; Osborne, A. P.; Ruecroft, G. Org. Process Res. & Dev. 2006, 10, 661-665.
Use of Lactamases for Industrial Scale Preparation of Chiral Synthons for Pharmaceutical Research.
Lloyd, M. C. Chimica Oggi; Chemistry Today. Chiral Technologies Today Supplement, 2005, pages 44-47.
Biocatalysis and Chemocatalysis – A Powerful Combination for the Preparation of Nantiomerically Pure a-amino Acids.
Holt-Tiffin, K. E. PharmaChem., 2004, 3, 2-4.
Application of Thermophilic Enzymes in Commercial Biotransformation Processes.
Taylor, I. N.; Brown, R. C.; Bycroft, M.; King, G.; Littlechild, J. A.; Lloyd, M. C.; Praquin, C.; Toogood, H. S.; Taylor, S. J. C. Biochemical Society Transactions, 2004, 32 (2), 290-292.
A Versatile Chemo-Enzymatic Route to Enantiomerically Pure β-Branched α-Amino Acids
Roff, G. J.; Lloyd, R. C.; Turner, N. J. J. Am. Chem. Soc. 2004, 126, 4098-4099.
The Use of a Thermostable Signature Amidase in the Resolution of the Bicylcic Synthon (rac)-γ-lactam.
Toogood, H. S.; Brown, R. C.; Line, K.; Lloyd, Keene, P. A.; Taylor, S. J. C.; McCague, R.; Littlechild, J. A. Tetrahedron, 2004, 60, 711-716.
Use of Hydrolases for the Synthesis of Cyclic Amino Acids.
Lloyd, R. C.; Lloyd, M. C.; Smith, M. E. B.; Holt, K. E., Swift, J. P.; Keene, P. A.; Taylor, S. J. C.; McCague, R. Tetrahedron, 2004, 60, 717-728.
Chemoenzymatic Approaches to the Dynamic Kinetic Asymmetric Synthesis of Aromatic Amino Acids.
Chaplin, J. A.; Levin, M. D.; Morgan, B.; Farid, N.; Li, J.; Zhu, Z.; McQuaid, J.; Nicholson, L. W.; Rand, C. A. and Burk, M. J. Tetrahedron: Asymmetry, 2004, 15, 2793-2796.
An Enantioconvergent Synthesis of (R)-4-Aryloxy-1-butyne-3-ols for Prostanoid Side Chains.
Fox, M. E.; Jackson, M.; Lennon, I. C.; McCague, R.; Parratt, J. S. Adv. Synth. Catal. 2002, 344, 50.
Immobilisation of the Thermostable L-aminoacylase from Thermococcus Litoralis to Generate a Resuable Industrial Biocatalyst.
Toogood, H. S.; Taylor, I. N.; Brown, R. C.; Taylor, S. J. C.; McCague, R.; Littlechild, J. A. Biocatalysis and Biotransformation 2002, 20 (4), 241-249.
Building on Success (Narrative article explaining how Chirotech has capitalised on the successful synthesis of the bicylic-g-lactam pharmaceutical intermediate for carbocyclic nucleosides and drug scaffolds).
Ruecroft, G.; Taylor, S. J. C. Chemistry in Britain 2002, September, 46.
A thermostable L-aminoacylase from Thermococcus litoralis: Cloning, Over-expression, Characterisation and Applications in Biotransformations.
Toogood, H. S.; Hollingsworth, E. J.; Brown, R. C.; Taylor, I. N.; Taylor, S. J.C.; McCague, R.; Littlechild, J. A. Extremeophiles 2002, 6, 111.
An Enzyme Library Approach to Biocatalysis: Development of Nitrilases for Enantioselective Production of Carboxylic Acid Derivatives.
DeSantis, G.; Zhu, Z.; Greenberg, W. A.; Wong, K.; Chaplin, J.; Hanson, S. R.; Farewell, B.; Nicholson, L. W.; Rand, C. L.; Weiner, D. P.; Robertson, D. E.; Burk, M. J. J. Am. Chem. Soc. 2002, 124, 9024.
Chemoenzymatic Synthesis of the Four Diastereoisomers of 4-Hydroxypipecolic Acid from N-Acetyl-(R,S)-allylglycine: Chiral Scaffolds for Drug Discovery.
Lloyd, R. C.; Smith, M. E. B.; Brick, D.; Taylor, S. J. C.; Chaplin, D. A.; McCague, R. Org. Process Res. Dev. 2002, 6, 762
An Efficient Stereoselective Synthesis of Z-(2S)- and Z-(2R)-2-tert-butoxycarbonylamino-6-hydroxyhex-4-enoic acid, Key Intermediates in the Synthesis of (2S,4S,5R)-(-)- and (2R,4R,5S)-(+)-bulgecinine.
Holt, K. E.; Swift, J. P.; Smith, M. E. B.; Taylor, S. J. C.; McCague, R. Tetrahedron Lett. 2002, 43,1545.
Parallel sheet secondary structure in γ-peptides.
Woll, M. G.; Lai, J. R.; Guzei, I. A.; Taylor, S. J. C.; Smith, M. E. B.; Gellman, S. H. J. Am. Chem. Soc. 2001, 123, 11077.
The purification of microbial biocatalysts by filtration and ammonium sulphate precipitation
Bycroft, M.; Taylor, I. N.; Weaver M.; Cole S. Pharmaceutical Technology Europe, 2001, 13, 44.
An efficient route to all eight stereoisomers of a tri-functionalised cyclopentane scaffolds for drug discovery
Smith, M. E. B.; Lloyd, M. C.; Derrien, N.; Lloyd, R. C.; Taylor, S. J. C.; Chaplin, D. A.; Casy, G.; McCague, R. Tetrahedron: Asymmetry 2001, 12, 703.
Cloning, expression and characterisation of pyrrolidone carboxyl peptidase from the archaeon Thermococcus litoralis
Singleton, M.; Taylor, S. J. C.; Parratt, J.; Littlechild, J. A. Extremeophiles, 2000, 4, 297.
Building chirality from the ground up: combinatorial libraries can benefit from starting single isomers
McCague, R. Modern Drug Discovery, 2000, 3, 29, 31-32, 34.
The use of PeptiCLEC-TR in the preparation of dipeptides
Faulconbridge, S. J.; Holt, K. E.; Lock, C. J.; Taylor, S. J. C.; Woods, M. Org. Process Res. Dev. 2000, 4, 563.
Choice of biocatalyst in the development of industrial biotransformations
Taylor, S. J. C.; Holt, K. E.; Brown, R. C.; Keene, P. A.; Taylor, I. N. Stereoselective Biocatalysis, ed. Ramesh N. Patel, Marcel Dekker, New York, 2000, 397.
Preparation of enantiomerically enriched aromatic β-amino acids via enzymatic resolution.
Faulconbridge, S. J.; Holt, K. E.; Sevillano, L. G.; Lock, C. J.; Tiffin, P. D.; Tremayne, N.; Winter, S. Tetrahedron Lett. 2000, 41, 2679.
Novel screening methods - the key to cloning commercially successful biocatalysts
Taylor, S. J. C.; Brown, R. C.; Keene, P. A.; Taylor, I. N. Bioorg. Med. Chem. 1999, 7, 2163.
In order to view some information you may need to download Adobe Reader.
SMService mark of The Dow Chemical Company
