Dowpharma Scientific Publications

Please find detailed a synopsis of the many papers and publications on Asymmetric Hydrogenation that scientists from Dowpharma^SM have published and contributed to since 1998. Due to copyright law we are unable to reproduce the papers online. As such we have quoted the publication reference.

Asymmetric Enamide Hydrogenation in the Synthesis of N-acetylcolchinol: A Key Intermediate for ZD6126.
Lennon, I. C.; Ramsden, J. A.; Brear, C. J.; Broady, S. D.; Muir, J. C. Tetrahedron Letters, 2007, 48, In Press.

1,2-Bis(2,5-diphenyl-phospholano)methane, A New Ligand for Asymmetric Hydrogenation.
Jackson, M.; Lennon, I. C. Tetrahedron Letters, 2007, 48, 1831-1834.

Enantioselective Hydrogenation: Phospholane Ligands
Cobley, C. J.; Moran, P. H. Handbook of Homogeneous Hydrogenation, Edited by J. G. De Vries and C. J. Elsevier. Weinhein, (Wiley-VCH), 2007, pages 773-831.

Use of Achiral (Diphosphine)RuCl2(Diamine) Precatalysts as a Practical Alternative to Sodium Borohydride for Ketone Reduction.
De Koning, P. D.; Jackson, M.; Lennon, I. C. Org. Process Res. & Dev. 2006, 10, 1054-1058.

Modular, Chiral P-Heterocycles in Asymmetric Catalysis.
Burk, M. J.; Ramsden, J. R. Handbook of Chiral Chemicals, Edited by David Ager. CRC Press, Taylor & Francis, Florida, 2006, Chapter 13, p249-268.

Complementary Technologies in the Metal Catalysed Asymmetric Hydrogenation of Ketones
Ramsden, J. R. Chimica Oggi: Chemistry Today 2005, 23, 46-49.

Identifying Stereoisomers of the Asymmetric Hydrogenation Catalyst [Me-BPE-Rh(COD)]+BF4-
Fox, M. E.; McCague, R. Chirality. 2005, 17, 177-185.

Efficient Synthesis of an Imidazole-Substituted d-Amino Acid by the Integration of Chiral Technologies.
Appleby, I.; Boulton, L. T.; Cobley, C. J.; Hill, C.; Hughes, M. L.; de Koning, P. D.; Lennon, I. C.; Praquin, C.; Ramsden, J. A.; Samuel, H. J.; Willis, N. Org. Lett.. 2005, 7, 1931-1934.

An Efficient Catalytic Asymmetric Route to 1-Aryl-2-imidazol-1-yl-ethanols.
Lennon, I. C.; Ramsden, J. A. Org. Process Res & Dev. 2005, 9, 110-112.

The application of DuPHOS Rhodium(I) catalysts for commercial scale asymmetric hydrogenation
Cobley, C. J.; Johnson, N. B.; Lennon, I. C.; McCague, R.; Ramsden, J. A.; Zanotti-Gerosa, A. Asymmetric Catalysis on Industrial Scale, Edited by H. U. Blaser and E. Schmidt. Weinhein, (Wiley-VCH), 2004, page 269.

Rapid Screening of Asymmetric Hydrogenation Catalysts Leading to Commercial Applications.
Lennon, I. C.; Moran, P. H. Chimica Oggi; Chemistry Today. Chiral Catalysis – asymmetric hydrogenation supplement 2004, p34-37.

A Versatile Chemo-Enzymatic Route to Enantiomerically Pure β-Branched α-Amino Acids
Roff, G. J.; Lloyd, R. C.; Turner, N. J. J. Am. Chem. Soc. 2004, 126, 4098-4099.

A Complementary Method to Obtain N-acyl Enamides Using the Heck Reaction: Extending the Substrate Scope for Asymmetric Hydrogenation
Meek, G.; Harrison, P. Tetrahedron Lett. 2004, 45, 9277.

Enantioselective hydrogenation of imines using a diverse library of catalysts derived from RuCl₂(diphosphine)(diamine)
Cobley, C. J.; Henschke, J. P. Adv. Synth. Catal. 2003, 345, 195.

Synthesis and applications of HexaPHEMP, a novel biaryl diphosphine ligand
Henschke, J. P.; Burk, M. J.; Malan, C. G.; Herzberg, D.; Peterson, J. A.; Wildsmith, A. J.; Cobley, C. J.; Casy, G. Adv. Synth. Catal. 2003, 345, 300.

DuPHOS Rhodium(I) Catalysts: a Comparison of COD Versus NBD Precatalysts Under Conditions of Industrial Application.
Cobley, C. J.; Lennon, I. C.; McCague, R.; Ramsden, J. A.; Zanotti-Gerosa, A. Catalysis of Organic Reactions New York, (Marcel Dekker), 2003, 329-340.

Anchored Homogeneous Catalysts: Some Studies into the Nature of the Catalytically Active Species
Goel, P.; Andersen, S.; Nair, J. J.; Reyes, C.; Gao, Y.; Tanielyan, S. K.; Augustine, R. L.; Appell, R.; Goralski, C.; Hawn, D. Catalysis of Organic Reactions New York, (Marcel Dekker), 2003, 523-529.

Effective Commercialisation of Asymmetric Hydrogenation Technology.
Casy, G.; Johnson, N. B.; Lennon, I. C. Chimica Oggi; Chemistry Today December 2003, 63-67.

Asymmetric Hydrogenation of Pharmaceutically Interesting Substrates
Lennon, I. C.; Moran, P. H. Curr. Opin. Drug Discovery Dev. 2003, 6, 855-875.

An Enantioselective Synthesis of (S)-(+)-3-Aminomethyl-5-methyl-hexanoic Acid via Asymmetric Hydrogenation
Burk, M. J.; de Koning, P. D.; Grote, T. M.; Hoekstra, M. S.; Hoge, G.; Jennings, R. A.; Kissel, W. S.; Le, T. V.; Lennon, I. C.; Mulhern, T. A.; Ramsden, J. A.; Wade, R. A. J. Org. Chem. 2003, 68, 5731.

Asymmetric Hydrogenation of a 4,4-Diaryl-3-butenoate; a novel Approach to Sertraline.
Boulton, L. T.; Lennon, I. C.; McCague, R., Org. Biomol. Chem. 2003, 1, 1094

Expanding the Family of Phospholane Ligands: 1,2-Bis(2,5-diphenylphospholano) ethane.
Pilkington, C. J.; Zanotti-Gerosa, A. Org. Lett. 2003, 5, 1273.

Industrially viable syntheses of highly enantiomerically enriched 1-arylalcohols via asymmetric hydrogenation
Chaplin, D.; Harrison, P.; Henschke, J. P.; Lennon, I. C.; Meek, G.; Moran, P.; Pilkington, C. J.; Ramsden, J. A.; Watkins, S.; Zanotti-Gerosa, A. Org. Process Res. Dev. 2003, 7, 89.

Highly efficient asymmetric hydrogenation of 2-methylene succinamic acid using a Rh-DuPHOS catalyst
Appell, R. B.; Cobley, C. J.; Goralski, C. T.; Lennon, I. C.; Praquin, C.; Sutterer, A. C.; Zanotti-Gerosa, A. Org. Process Res. Dev. 2003, 7, 407.

Exceptionally Active and Selective Ketone Hydrogenation Catalysts.
Lennon, I. C.; de Koning, P. D., Ramsden, J. A. PharmaChem, April 2003, 24.

The Application of Asymmetric Hydrogenation for the Manufacture of Pharmaceutical Intermediates: The Need for Catalyst Diversity.
Pilkington, C. J.; Lennon, I. C. Synthesis, 2003, 1639.

The synthesis of S18986, a chiral AMPA receptor modulator, via catalytic asymmetric hydrogenation.
Cobley, C. J.; Foucher, E.; Lecouve, J-P.; Lennon, I. C.; Ramsden, J. A.; Thominot, G. Tetrahedron: Asymmetry, 2003, 14, 3431.

Concise synthesis of a new xylyl-biaryl phosphine ligand for asymmetric hydrogenation of ketones.
Henschke, J. P.; Zanotti-Gerosa, A.; Moran, P.; Harrison, P.; Mullen, B.; Casy, G.; Lennon, I. C. Tetrahedron Lett. 2003, 44, 4379.

Asymmetric catalysis as an industry standard
De Koning, P. D. Chemical & Engineering News, March 2001, 251.

Phosphonites based on the paracyclophane backbone: New ligands for highly selective Rhodium-catalyzed asymmetric hydrogenation
Zanotti-Gerosa, A.; Malan, C.; Herzberg, D. Org. Lett. 2001, 3, 3687.

Highly selective directed hydrogenation of single enantiomer 4-(tert-butoxycarbonylamino) -cyclopent-1-enecarboxylic acid methyl esters
Smith, M. E. B.; Derrien, N.; Lloyd, M. C.; Taylor, S. J. C.; Chaplin, D. A.; McCague, R. Tetrahedron Lett. 2001, 42, 1347.

On the economic application of DuPHOS rhodium(I) catalysts: a comparison of COD versus NBD precatalysts
Cobley, C. J.; Lennon, I. C.; McCague, R.; Ramsden, J. A.; Zanotti-Gerosa A. Tetrahedron Lett. 2001, 42, 7481.

Modular phospholane ligands in asymmetric catalysis
Burk, M. J. Acc. Chem. Res. 2000, 33, 363.

Chiral 1,1'-bis(phosphetano)ferrocenes: new ligands for asymmetric catalytic hydrogenation of itaconate derivatives
Berens, U.; Burk, M. J.; Gerlach, A.; Hems, W. Angew. Chem, Int. Ed. 2000, 39, 1981.

Tethering Technology: Anchored Homogeneous Catalysts.
Brandts, J. A. M.; Donkervoort, J. G.; Ansems, C.; Berben, P. H.; Gerlach, A.; Burk, M. J. Catalysis of Organic Reactions New York, (Marcel Dekker), 2000, 573-581.

An immobilized homogeneous catalyst for efficient and selective hydrogenation of functionalized aldehydes, alkenes and alkynes
Burk, M. J.; Gerlach, A.; Sémeril, D. J. Org. Chem. 2000, 65, 8933.

A catalyst for efficient and highly enantioselective hydrogenation of aromatic, heteroaromatic, and α,β-unsaturated ketones
Burk, M. J.; Hems W.; Herzberg D.; Malan, C.; Zanotti-Gerosa, A. Org. Lett. 2000, 26, 4173.

Asymmetric Catalysis: Development and Application of the DuPHOS ligands
Burk, M. J.; In Handbook of Chiral Chemicals, New York, (Marcel Dekker), 1999, Ch 18, 339.

Me-DuPHOS-Rh-catalyzed asymmetric synthesis of the pivotal glutarate intermediate for candoxatril
Burk, M. J.; Bienewald, F.; Challenger, S.; Derrick, A.; Ramsden, J. A. J. Org. Chem. 1999, 64, 3290.

Asymmetric Hydrogenation Reactions Mediated by a New Class of Bicyclic Bisphosphinites
Derrien, N.; Dousson, C. B.; Roberts, S. M.; Berens, U.; Burk, M. J.; Ohff M. Tetrahedron: Asymmetry 1999, 10, 3341.

Asymmetric synthesis of β-amino alcohols and 1,2-diamines through DuPHOS-Rh catalyzed hydrogenation
Burk, M. J.; Johnson, N. B.; Lee, Jeffrey R. Tetrahedron Lett. 1999, 40, 6685.

Practical access to 2-alkylsuccinates through asymmetric catalytic hydrogenation of Stobbe-derived itaconates
Burk, M. J.; Bienewald, F.; Harris, M.; Zanotti-Gerosa, A. Angew. Chem. Int. Ed. 1998, 37, 1931.

The DuPHOS ligands – A historical account
Burk, M. J. Chemtracts. 1998, 11, 787.

A three-step procedure for asymmetric catalytic reductive amidation of ketones
Burk, M. J.; Casy, G.; Johnson, N. B. J. Org. Chem. 1998, 63, 6084.

Development of Asymmetric Catalytic Processes: From Conception to Commercialization
Burk, M. J. 3^rd Scale-up of Chemical Processes, Conference Proceedings, St. Helier, United Kingdom, Sept 21-24, 1998, 270-316. Publ. Scientific Update, Mayfield, U.K.

Diverse building blocks through asymmetric hydrogenation
Burk, M. J. Spec. Chemical 1998, 18, 58.

Unnatural α-Amino Acids via Asymmetric Hydrogenation of Enamides
Burk, M. J.; Bienewald F. In Transition Metals for Organic Synthesis and Fine Chemicals, Wiley-VCH, Weinheim, Germany, 1998, Vol. 2, 13.

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Dowpharma Relaunches Web Site, Will Make Donation to UNICEF Dow Expands Presence in Pharmaceutical Market, Uniting Existing Offers Under Dowpharma Portfolio Dowpharma Announces New Capabilities in Asymmetric Hydroformylation for Pharmaceutical Applications License of JST Catalyst Technology Expands Dowpharma’s Chiral Commercial Production Capabilities Dowpharma Signs Agreement with Japanese Distributor to Market Pharmaceutical Services in Japan Events Calendar Contact Us	Dowpharma Scientific Publications Please find detailed a synopsis of the many papers and publications on Asymmetric Hydrogenation that scientists from Dowpharma^SM have published and contributed to since 1998. Due to copyright law we are unable to reproduce the papers online. As such we have quoted the publication reference. Asymmetric Enamide Hydrogenation in the Synthesis of N-acetylcolchinol: A Key Intermediate for ZD6126. Lennon, I. C.; Ramsden, J. A.; Brear, C. J.; Broady, S. D.; Muir, J. C. Tetrahedron Letters, 2007, 48, In Press. 1,2-Bis(2,5-diphenyl-phospholano)methane, A New Ligand for Asymmetric Hydrogenation. Jackson, M.; Lennon, I. C. Tetrahedron Letters, 2007, 48, 1831-1834. Enantioselective Hydrogenation: Phospholane Ligands Cobley, C. J.; Moran, P. H. Handbook of Homogeneous Hydrogenation, Edited by J. G. De Vries and C. J. Elsevier. Weinhein, (Wiley-VCH), 2007, pages 773-831. Use of Achiral (Diphosphine)RuCl2(Diamine) Precatalysts as a Practical Alternative to Sodium Borohydride for Ketone Reduction. De Koning, P. D.; Jackson, M.; Lennon, I. C. Org. Process Res. & Dev. 2006, 10, 1054-1058. Modular, Chiral P-Heterocycles in Asymmetric Catalysis. Burk, M. J.; Ramsden, J. R. Handbook of Chiral Chemicals, Edited by David Ager. CRC Press, Taylor & Francis, Florida, 2006, Chapter 13, p249-268. Complementary Technologies in the Metal Catalysed Asymmetric Hydrogenation of Ketones Ramsden, J. R. Chimica Oggi: Chemistry Today 2005, 23, 46-49. Identifying Stereoisomers of the Asymmetric Hydrogenation Catalyst [Me-BPE-Rh(COD)]+BF4- Fox, M. E.; McCague, R. Chirality. 2005, 17, 177-185. Efficient Synthesis of an Imidazole-Substituted d-Amino Acid by the Integration of Chiral Technologies. Appleby, I.; Boulton, L. T.; Cobley, C. J.; Hill, C.; Hughes, M. L.; de Koning, P. D.; Lennon, I. C.; Praquin, C.; Ramsden, J. A.; Samuel, H. J.; Willis, N. Org. Lett.. 2005, 7, 1931-1934. An Efficient Catalytic Asymmetric Route to 1-Aryl-2-imidazol-1-yl-ethanols. Lennon, I. C.; Ramsden, J. A. Org. Process Res & Dev. 2005, 9, 110-112. The application of DuPHOS Rhodium(I) catalysts for commercial scale asymmetric hydrogenation Cobley, C. J.; Johnson, N. B.; Lennon, I. C.; McCague, R.; Ramsden, J. A.; Zanotti-Gerosa, A. Asymmetric Catalysis on Industrial Scale, Edited by H. U. Blaser and E. Schmidt. Weinhein, (Wiley-VCH), 2004, page 269. Rapid Screening of Asymmetric Hydrogenation Catalysts Leading to Commercial Applications. Lennon, I. C.; Moran, P. H. Chimica Oggi; Chemistry Today. Chiral Catalysis – asymmetric hydrogenation supplement 2004, p34-37. A Versatile Chemo-Enzymatic Route to Enantiomerically Pure β-Branched α-Amino Acids Roff, G. J.; Lloyd, R. C.; Turner, N. J. J. Am. Chem. Soc. 2004, 126, 4098-4099. A Complementary Method to Obtain N-acyl Enamides Using the Heck Reaction: Extending the Substrate Scope for Asymmetric Hydrogenation Meek, G.; Harrison, P. Tetrahedron Lett. 2004, 45, 9277. Enantioselective hydrogenation of imines using a diverse library of catalysts derived from RuCl₂(diphosphine)(diamine) Cobley, C. J.; Henschke, J. P. Adv. Synth. Catal. 2003, 345, 195. Synthesis and applications of HexaPHEMP, a novel biaryl diphosphine ligand Henschke, J. P.; Burk, M. J.; Malan, C. G.; Herzberg, D.; Peterson, J. A.; Wildsmith, A. J.; Cobley, C. J.; Casy, G. Adv. Synth. Catal. 2003, 345, 300. DuPHOS Rhodium(I) Catalysts: a Comparison of COD Versus NBD Precatalysts Under Conditions of Industrial Application. Cobley, C. J.; Lennon, I. C.; McCague, R.; Ramsden, J. A.; Zanotti-Gerosa, A. Catalysis of Organic Reactions New York, (Marcel Dekker), 2003, 329-340. Anchored Homogeneous Catalysts: Some Studies into the Nature of the Catalytically Active Species Goel, P.; Andersen, S.; Nair, J. J.; Reyes, C.; Gao, Y.; Tanielyan, S. K.; Augustine, R. L.; Appell, R.; Goralski, C.; Hawn, D. Catalysis of Organic Reactions New York, (Marcel Dekker), 2003, 523-529. Effective Commercialisation of Asymmetric Hydrogenation Technology. Casy, G.; Johnson, N. B.; Lennon, I. C. Chimica Oggi; Chemistry Today December 2003, 63-67. Asymmetric Hydrogenation of Pharmaceutically Interesting Substrates Lennon, I. C.; Moran, P. H. Curr. Opin. Drug Discovery Dev. 2003, 6, 855-875. An Enantioselective Synthesis of (S)-(+)-3-Aminomethyl-5-methyl-hexanoic Acid via Asymmetric Hydrogenation Burk, M. J.; de Koning, P. D.; Grote, T. M.; Hoekstra, M. S.; Hoge, G.; Jennings, R. A.; Kissel, W. S.; Le, T. V.; Lennon, I. C.; Mulhern, T. A.; Ramsden, J. A.; Wade, R. A. J. Org. Chem. 2003, 68, 5731. Asymmetric Hydrogenation of a 4,4-Diaryl-3-butenoate; a novel Approach to Sertraline. Boulton, L. T.; Lennon, I. C.; McCague, R., Org. Biomol. Chem. 2003, 1, 1094 Expanding the Family of Phospholane Ligands: 1,2-Bis(2,5-diphenylphospholano) ethane. Pilkington, C. J.; Zanotti-Gerosa, A. Org. Lett. 2003, 5, 1273. Industrially viable syntheses of highly enantiomerically enriched 1-arylalcohols via asymmetric hydrogenation Chaplin, D.; Harrison, P.; Henschke, J. P.; Lennon, I. C.; Meek, G.; Moran, P.; Pilkington, C. J.; Ramsden, J. A.; Watkins, S.; Zanotti-Gerosa, A. Org. Process Res. Dev. 2003, 7, 89. Highly efficient asymmetric hydrogenation of 2-methylene succinamic acid using a Rh-DuPHOS catalyst Appell, R. B.; Cobley, C. J.; Goralski, C. T.; Lennon, I. C.; Praquin, C.; Sutterer, A. C.; Zanotti-Gerosa, A. Org. Process Res. Dev. 2003, 7, 407. Exceptionally Active and Selective Ketone Hydrogenation Catalysts. Lennon, I. C.; de Koning, P. D., Ramsden, J. A. PharmaChem, April 2003, 24. The Application of Asymmetric Hydrogenation for the Manufacture of Pharmaceutical Intermediates: The Need for Catalyst Diversity. Pilkington, C. J.; Lennon, I. C. Synthesis, 2003, 1639. The synthesis of S18986, a chiral AMPA receptor modulator, via catalytic asymmetric hydrogenation. Cobley, C. J.; Foucher, E.; Lecouve, J-P.; Lennon, I. C.; Ramsden, J. A.; Thominot, G. Tetrahedron: Asymmetry, 2003, 14, 3431. Concise synthesis of a new xylyl-biaryl phosphine ligand for asymmetric hydrogenation of ketones. Henschke, J. P.; Zanotti-Gerosa, A.; Moran, P.; Harrison, P.; Mullen, B.; Casy, G.; Lennon, I. C. Tetrahedron Lett. 2003, 44, 4379. Asymmetric catalysis as an industry standard De Koning, P. D. Chemical & Engineering News, March 2001, 251. Phosphonites based on the paracyclophane backbone: New ligands for highly selective Rhodium-catalyzed asymmetric hydrogenation Zanotti-Gerosa, A.; Malan, C.; Herzberg, D. Org. Lett. 2001, 3, 3687. Highly selective directed hydrogenation of single enantiomer 4-(tert-butoxycarbonylamino) -cyclopent-1-enecarboxylic acid methyl esters Smith, M. E. B.; Derrien, N.; Lloyd, M. C.; Taylor, S. J. C.; Chaplin, D. A.; McCague, R. Tetrahedron Lett. 2001, 42, 1347. On the economic application of DuPHOS rhodium(I) catalysts: a comparison of COD versus NBD precatalysts Cobley, C. J.; Lennon, I. C.; McCague, R.; Ramsden, J. A.; Zanotti-Gerosa A. Tetrahedron Lett. 2001, 42, 7481. Modular phospholane ligands in asymmetric catalysis Burk, M. J. Acc. Chem. Res. 2000, 33, 363. Chiral 1,1'-bis(phosphetano)ferrocenes: new ligands for asymmetric catalytic hydrogenation of itaconate derivatives Berens, U.; Burk, M. J.; Gerlach, A.; Hems, W. Angew. Chem, Int. Ed. 2000, 39, 1981. Tethering Technology: Anchored Homogeneous Catalysts. Brandts, J. A. M.; Donkervoort, J. G.; Ansems, C.; Berben, P. H.; Gerlach, A.; Burk, M. J. Catalysis of Organic Reactions New York, (Marcel Dekker), 2000, 573-581. An immobilized homogeneous catalyst for efficient and selective hydrogenation of functionalized aldehydes, alkenes and alkynes Burk, M. J.; Gerlach, A.; Sémeril, D. J. Org. Chem. 2000, 65, 8933. A catalyst for efficient and highly enantioselective hydrogenation of aromatic, heteroaromatic, and α,β-unsaturated ketones Burk, M. J.; Hems W.; Herzberg D.; Malan, C.; Zanotti-Gerosa, A. Org. Lett. 2000, 26, 4173. Asymmetric Catalysis: Development and Application of the DuPHOS ligands Burk, M. J.; In Handbook of Chiral Chemicals, New York, (Marcel Dekker), 1999, Ch 18, 339. Me-DuPHOS-Rh-catalyzed asymmetric synthesis of the pivotal glutarate intermediate for candoxatril Burk, M. J.; Bienewald, F.; Challenger, S.; Derrick, A.; Ramsden, J. A. J. Org. Chem. 1999, 64, 3290. Asymmetric Hydrogenation Reactions Mediated by a New Class of Bicyclic Bisphosphinites Derrien, N.; Dousson, C. B.; Roberts, S. M.; Berens, U.; Burk, M. J.; Ohff M. Tetrahedron: Asymmetry 1999, 10, 3341. Asymmetric synthesis of β-amino alcohols and 1,2-diamines through DuPHOS-Rh catalyzed hydrogenation Burk, M. J.; Johnson, N. B.; Lee, Jeffrey R. Tetrahedron Lett. 1999, 40, 6685. Practical access to 2-alkylsuccinates through asymmetric catalytic hydrogenation of Stobbe-derived itaconates Burk, M. J.; Bienewald, F.; Harris, M.; Zanotti-Gerosa, A. Angew. Chem. Int. Ed. 1998, 37, 1931. The DuPHOS ligands – A historical account Burk, M. J. Chemtracts. 1998, 11, 787. A three-step procedure for asymmetric catalytic reductive amidation of ketones Burk, M. J.; Casy, G.; Johnson, N. B. J. Org. Chem. 1998, 63, 6084. Development of Asymmetric Catalytic Processes: From Conception to Commercialization Burk, M. J. 3^rd Scale-up of Chemical Processes, Conference Proceedings, St. Helier, United Kingdom, Sept 21-24, 1998, 270-316. Publ. Scientific Update, Mayfield, U.K. Diverse building blocks through asymmetric hydrogenation Burk, M. J. Spec. Chemical 1998, 18, 58. Unnatural α-Amino Acids via Asymmetric Hydrogenation of Enamides Burk, M. J.; Bienewald F. In Transition Metals for Organic Synthesis and Fine Chemicals, Wiley-VCH, Weinheim, Germany, 1998, Vol. 2, 13. ^SMService mark of The Dow Chemical Company
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